TABLE 2.
Comparison of the performance of some of the LFIC test strips authorized for nucleic acid (2022c) by the U.S. Food and Drug Administration emergency use.
| Product name | Technology | Target | Characteristic | PPV,% (95% CI) | NPV,% (95% CI) | Detection limit, copies/μL | Testing time | Reference |
|---|---|---|---|---|---|---|---|---|
| ID NOW COVID-19 | Isothermal nicking enzyme amplification reaction | RdRp gene | Qualitative | 94.5 (85.1–98.1) | 99.3 (96.4–99.9) | .511 | 5–13 min | Babic et al. (2021) |
| Sherlock CRISPR SARS-CoV-2 kit | RT-LAMP,CRISPR-Cas13a system | N and ORF1ab gene | Quantitative | 100% accuracy compared to RT-PCR | 6.75 | 50 min | Khan et al. (2021) | |
| SARS-CoV-2 RNA DETECTR Assay | RT-LAMP,CRISPR-Cas12 system | N and E gene | Qualitative | 95 (/) | 100 (/) | 10 | 45 min | Broughton et al. (2020) |
| Cue COVID-19 test | Isothermal nucleic acid amplification tests technology | N gene | Qualitative | 91.7 (/) | 98.4 (/) | — | After 20 min | Donato et al. (2021) |