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. 2023 Jan 10;10:1082657. doi: 10.3389/fcell.2022.1082657

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Copyright © 2023 Yaghoobi, Nazerian, Meymand, Ansari, Nazerian and Niknejad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study design. (A) Isolation and characterization of Mesenchymal stem cell-derived exosomes (MSC exosomes) by the ultra-centrifuge method. (B) Antibodies against ErbB4 conjugate on the surface of constructive liposomes. (C) Exosomes derived from end-MSCs will be incubated with the targeted liposomes to make exosome-liposome hybrids. (D) Non-viral S/MAR episomal vector will be constructed containing: sgRNA, HIF-1 sensitive promotor (evidence), dCas 9, VP64, GFP gene sequences, doxycycline sensitive gene, and ribosomal skipping 2A sequences between the genes. (E) Electroporation will be used to encapsulate the designed episomal S/MAR vector into the hybrid. (F) The liposome-exosome hybrids will be added to the trophoblast cell media and the episomal vector will specifically enter the trophoblast.