Fig. 1.

The metabolic pathways involved in a 6-dEB and b taxadiene biosynthesis. SucCD succinyl-CoA synthetase, Sbm “Sleeping beauty mutase”, MCE methylmalonyl-CoA epimerase, PCC propionyl-CoA carboxylase, YgfG methylmalonyl-CoA decarboxylase, DEBS123 deoxyerythronlide B synthase, PrpE propionyl-CoA synthetase, YgfH propionyl-CoA:succinate CoA transferase, DXS 1-deoxy-D-xylulose-5-phosphate synthase, DXR 1-deoxy-D-xylulose-5-phosphate reductoisomerase, IspD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, IspE 4-diphosphocytidyl-2-C-methylerythritol kinase, IspF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, IspG 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase, IspH 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, IPP isopentenyl diphosphate isomerase, IspA geranyl diphosphate synthase/farnesyl diphosphate synthase, GGPPS geranylgeranyl diphosphate synthase, TXS taxadiene synthase