Table 1.
Sample Descriptive Data
| Non-Carrier (n=26) | Cognitively Unimpaired PSEN1 E280A Carrier (n=35) | PSEN1 E280A Carrier with MCI due to ADAD (n=5) | Test statistic, significance, and effect size | |
|---|---|---|---|---|
| Age (years) | 36.68 (6.52) | 30.46 (5.28) | 47.60 (1.67) | t=3.92, p<.001, d=1.01*** |
| Education (years) | 11.42 (4.30) | 11.14 (3.39) | 7.00 (2.83) | t=0.29, p=.39 |
| MMSE | 28.77 (1.14) | 28.06 (1.19) | 22.60 (4.34) | t=2.36, p=.01, d=0.61* |
| FAST (2 < # < 5) | 0 | 0 | 5 | n/a |
| Sex (males:females) | 11:15 | 11:24 | 1:4 | χ2=0.77, p=.38 |
*p<.05, **p <.01, ***p <.001; Abbreviations: PSEN1 = Presenilin1; FAST = Functional Assessment Staging Tool; MMSE = Mini-Mental State Exam; MCI = mild cognitive impairment; ADAD = autosomal dominant Alzheimer’s disease.