Table 2.
MESERO Task Performance (Accuracy) and Reaction Time in the Colombian Kindred
| Non-Carrier (n=26) | Cognitively Unimpaired PSEN1 E280A Carrier (n=35) | PSEN1 E280A Carrier with MCI due to ADAD (n=5) | Test statistic, significance, and effect size | |
|---|---|---|---|---|
| MESERO Total Score (out of 80) | 73.46 (5.67) | 70.77 (6.51) | 64.60 (8.68) | U=312, p=.04, r=.27* |
| MESERO Related Trials Sub-Score (out of 40) | 35.77 (2.89) | 33.91 (4.15) | 31.60 (5.27) | U=312.5, p=.04, r=.27* |
| MESERO Unrelated Trials Sub-Score (out of 40) | 37.69 (3.31) | 36.85 (3.48) | 33.00 (3.53) | U=357 p=.15, r=0.19 |
| 4-Item Object Load Score (out of 40) | 37.31 (3.18) | 35.54 (4.19) | 32.40 (5.32) | U=300.5, p=.02, r=0.29* |
| 6-Item Object Load Score (out of 40) | 36.15 (2.69) | 35.23 (3.04) | 32.20 (3.42) | U=366.5, p=.19, r=0.17 |
| Average RT (ms)t | 2817.17 (1039.54) | 2578.94 (793.71) | 3563.70 (1197.65) | U=392 p=.36 |
| Average RT Related Trials (ms) t | 2856.27 (1137.84) | 2623.86 (914.46) | 3524.98 (1270.83) | U=392 p=.36 |
| Average RT Unrelated Trials (ms) t | 2778.07 (1039.55) | 2534.03 (734.08) | 3602.43 (1128.58) | U=393, p=.37 |
| Average RT 4-Item Trials (ms) t | 2636.13 (973.95) | 2483.92 (864.50) | 3445.37 (1005.44) | U=399, p=.56 |
| Average RT 6- Item Trials (ms) t | 2998.21 (1178.13) | 2673.96 (812.29) | 3682.03 (1427.50) | U=373, p=.33 |
*p<.05, **p <.01, ***p <.001; Abbreviations: PSEN1 = Presenilin1; MESERO = Memory for Semantically Related Objects Test; MCI = mild cognitive impairment; ADAD = autosomal dominant Alzheimer’s disease; RT = reaction time; ms = milliseconds; † RT analyses were conducted after removing one non-carrier who had a very large average RT that was >10000 ms.