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. 2023 Jan 10;9:1066029. doi: 10.3389/fmolb.2022.1066029

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Copyright © 2023 Spassov, Atanasova and Doytchinova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of the nitrogen atom of the piperazine ring in the potency of the DDD85646 series of compounds. IC₅₀ towards Homo sapiens NMT1 is shown. Substitution of the indicated nitrogen atom with a carbon reduces potency by 1,328-fold.