Table 4.

MR results and sensitivity analyses between steroid hormones and AMD in the discovery stage.

	P (MR results)					P (Cochrane's Q)		P (Pleiotropy)
	IVW	MR-Egger	WM	MLE	MR-RAPS	IVW	MR-Egger	MR-Egger regression	MR-PRESSO
Aldo	0.39	0.71	0.58	0.64	0.65	0.89	0.89	0.46	0.920
A4	0.79	0.59	0.79	0.52	0.53	0.38	0.33	0.63	0.271
P4	0.82	0.70	0.45	0.94	0.94	0.18	0.15	0.74	0.196
17-OHP	0.43	0.21	0.74	0.73	0.74	0.51	0.54	0.29	0.564
T/E2	0.75	0.78	0.81	0.68	0.68	0.07	0.06	0.67	0.066

MR, Mendelian randomization; IVW, Inverse variance weighted; WM, Weighted median; MLE, maximum likelihood estimator; MR-RAPS, MR robust adjusted profile score; Aldo, aldosterone; A4, androstenedione; P4, progesterone; 17-OHP, hydroxyprogesterone; T/E, Testosterone_Estradiol_Ratio.