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(A) Market shares (%) of biosimilar TNF-alpha inhibitors in Portugal. Data at the national/regional level are provided for infliximab (2016–2021), etanercept (2017–2021), and adalimumab biosimilars (2018–2021). (B) Geographical location of low-(<50%), intermediate-(50–75%), and high-uptake (>75%) regions for TNF-alpha inhibitors in Portugal. (C) List of Portuguese health areas sorted in increasing order of biosimilars uptake (%).
