Table 2.
Univariate and multivariate Cox regression models used to study the association of SIRI with mortality in patients with AIS.
| Clinical outcome | Non-adjusted | Model I | Model II | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p -value | HR (95% CI) | p -value | HR (95% CI) | p -value | |
| 90-day all-cause mortality | ||||||
| Before PSM | ||||||
| SIRI (≥4.57) | 2.20 (1.88–2.58) | <0.001 | 2.18 (1.86–2.55) | <0.001 | 1.56 (1.30–1.89) | <0.001 |
| SIRI (quartile) | ||||||
| <2.59 | 1 | 1 | 1 | |||
| 2.59–4.57 | 1.02 (0.78–1.32) | 0.895 | 1.02 (0.79–1.33) | 0.859 | 1.00 (0.77–1.31) | 0.994 |
| 4.57–7.30 | 1.70 (1.34–2.16) | <0.001 | 1.71 (1.34–2.17) | <0.001 | 1.41 (1.10–1.81) | 0.008 |
| >7.30 | 2.53 (2.02–3.17) | <0.001 | 2.54 (2.02–3.18) | <0.001 | 1.66 (1.26–2.19) | <0.001 |
| p for trend | <0.001 | <0.001 | <0.001 | |||
| After PSM | ||||||
| SIRI (≥4.57) | 1.46 (1.16–1.84) | 0.001 | 1.50 (1.19–1.89) | 0.001 | 1.47 (1.16–1.86) | 0.001 |
| 30-day all-cause mortality | ||||||
| Before PSM | ||||||
| SIRI (≥4.57) | 2.21 (1.85–2.64) | <0.001 | 2.16 (1.81–2.58) | <0.001 | 1.54 (1.25–1.90) | <0.001 |
| SIRI (quartile) | ||||||
| <2.59 | 1 | 1 | 1 | |||
| 2.59–4.57 | 0.96 (0.71–1.29) | 0.772 | 0.95 (0.71–1.28) | 0.760 | 0.94 (0.69–1.27) | 0.683 |
| 4.57–7.30 | 1.66 (1.27–2.17) | <0.001 | 1.63 (1.25–2.13) | <0.001 | 1.35 (1.02–1.79) | 0.036 |
| >7.30 | 2.47 (1.92–3.18) | <0.001 | 2.43 (1.88–3.13) | <0.001 | 1.58 (1.16–2.14) | 0.004 |
| p for trend | <0.001 | <0.001 | 0.002 | |||
| After PSM | ||||||
| SIRI (≥4.57) | 1.42 (1.10–1.84) | 0.007 | 1.46 (1.12–1.89) | 0.004 | 1.41 (1.08–1.84) | 0.011 |
| 1-year all-cause mortality | ||||||
| Before PSM | ||||||
| SIRI (≥4.57) | 2.01 (1.75–2.32) | <0.001 | 2.01 (1.75–2.32) | <0.001 | 1.44 (1.23–1.70) | <0.001 |
| SIRI (quartile) | ||||||
| <2.59 | 1 | 1 | 1 | |||
| 2.59–4.57 | 0.96 (0.76–1.21) | 0.717 | 0.97 (0.77–1.22) | 0.781 | 0.95 (0.75–1.20) | 0.647 |
| 4.57–7.30 | 1.60 (1.29–1.97) | <0.001 | 1.62 (1.31–1.99) | <0.001 | 1.37 (1.09–1.71) | 0.006 |
| >7.30 | 2.27 (1.86–2.77) | <0.001 | 2.30 (1.88–2.82) | <0.001 | 1.58 (1.23–2.02) | <0.001 |
| p for trend | <0.001 | <0.001 | <0.001 | |||
| After PSM | ||||||
| SIRI (≥4.57) | 1.35 (1.10–1.66) | 0.004 | 1.40 (1.14–1.72) | 0.001 | 1.41 (1.15–1.74) | 0.001 |
Non-adjusted model was adjusted for none.
Model I was adjusted for age, gender, and ethnicity.
Model II was adjusted for age, gender, ethnicity, hypertension, congestive heart failure, chronic pulmonary disease, diabetes mellitus, malignant cancer, severe liver disease, atrial fibrillation, white blood cell, hemoglobin, serum creatinine, serum sodium, serum potassium, anion gap, prothrombin time, activated partial thromboplastin time, thrombolysis, and thrombectomy.
SIRI, Systemic Inflammation Response Index; HR, hazard ratio; CI, confidence interval; PSM, propensity score matching; AIS, acute ischemic stroke.