Table 3.

Sensitivity analysis of the association between SIRI and all-cause mortality in AIS patients (adjustment through multivariate Cox regression models).

	Case, n (%)	Univariate		Multivariate
		HR (95% CI)	p -value	HR (95% CI)	p -value
90-day all cause mortality
The first sequence of diagnosis of AIS
SIRI (≥4.57)	370 (32.5)	2.26 (1.81–2.83)	<0.001	1.47 (1.11–1.96)	0.008
Non-first sequence of diagnosis of AIS
SIRI (≥4.57)	457 (50.4)	1.99 (1.59–2.49)	<0.001	1.57 (1.21–2.05)	0.001
30-day all cause mortality
The first sequence of diagnosis of AIS
SIRI (≥4.57)	370 (32.5)	2.52 (1.97–3.22)	<0.001	1.55 (1.14–2.10)	0.005
Non-first sequence of diagnosis of AIS
SIRI (≥4.57)	457 (50.4)	1.87 (1.44–2.42)	<0.001	1.42 (1.05–1.93)	0.025
1-year all cause mortality
The first sequence of diagnosis of AIS
SIRI (≥4.57)	370 (32.5)	1.99 (1.63–2.45)	<0.001	1.33 (1.03–1.72)	0.031
Non-first sequence of diagnosis of AIS
SIRI (≥4.57)	457 (50.4)	1.86 (1.52–2.27)	<0.001	1.55 (1.22–1.97)	<0.001

Non-adjusted model was adjusted for none.

Adjusted model was adjusted for age, gender, ethnicity, hypertension, congestive heart failure, chronic pulmonary disease, diabetes mellitus, malignant cancer, severe liver disease, atrial fibrillation, white blood cell, hemoglobin, serum creatinine, serum sodium, serum potassium, anion gap, prothrombin time, activated partial thromboplastin time, thrombolysis, and thrombectomy.

SIRI, Systemic Inflammation Response Index; HR, hazard ratio; CI, confidence interval; AIS, acute ischemic stroke.