Table 5.
Comparison of the clinical features of HBoV and hMPV single infections [n (%)].
| Clinical Information | HBoV single infection | hMPV single infection | P values | |
|---|---|---|---|---|
| Demography | Sex, n (%) male | 181(67.04) | 71(67.6) | 1 |
| Age, months | 17 (11, 30) | 11 (4, 40) | 0.007 | |
| Clinical presentation | Pulse oxygen below 92%, n (%) | 31(11.5) | 4(3.8) | 0.028 |
| Fever, n (%) | 184(68.1) | 59(56.2) | 0.031 | |
| Cough, n (%) | 260 (96.3) | 104 (99.0) | 0.193 | |
| Wheeze, n (%) | 130(48.1) | 53(50.5) | 0.73 | |
| Stuffy nose rhinorrhea, n (%) | 114(42.2) | 46(43.8) | 0.817 | |
| Dyspnea, n (%) | 26(9.6) | 3(2.9) | 0.001 | |
| Shortness of breath, n (%) | 47(17.4) | 8(7.6) | 0.022 | |
| Cyanosis, n (%) | 7 (2.6) | 2 (1.9) | 0.74 | |
| Gastrointestinal symptoms, n (%) | 61(22.6) | 24(22.9) | 1 | |
| Auscultation | Low breath sounds, n (%) | 14(5.6) | 3(2.9) | 0.417 |
| Stridor, n (%) | 125 (46.3) | 53 (50.5) | 0.491 | |
| Cracklesfing, n (%) | 194(71.9) | 81(77.1) | 0.363 | |
| Ancillary examinations | WBC count, × 109/L | 9.86 (7.62, 12.84) | 8.8 (6.68, 12.28) | 0.018 |
| Percentage of neutrophils, % | 44.95 (29.9, 62.33) | 31.3 (21.15, 50.65) | 0.001 | |
| PLT count, × 109/ml | 337 (268, 420) | 321 (250, 440) | 0.652 | |
| CRP > 8 mg/L, n (%) | 99(36.7) | 26(24.8) | 0.038 | |
| ALT > 40 U/L, n (%) | 19(7.0) | 11(10.5) | 0.291 | |
| LDH > 382 U/L, n (%) | 157(58.1) | 57(54.3) | 0.561 | |
| CD3+, % | 60.9 (54.8, 68.4) | 59.9 (53.6, 67.9) | 0.716 | |
| CD3 + CD4+, % | 34.75 ± 10.46 | 36.55 ± 10.75 | 0.189 | |
| CD3 + CD8+, % | 21.7 (17.1, 27.9) | 20.6 (16.23, 25.35) | 0.13 | |
| CD4+/CD8+, % | 1.7 (1.2, 2.38) | 1.7 (1.2, 2.5) | 0.402 | |
| CD3-CD19+, % | 26.1 (19.28, 31.95) | 23.25 (15.03, 32.2) | 0.079 | |
| CD3-CD16 + CD56+, % | 8.2 (5.03, 14.2) | 10.90 (5.68, 19.4) | 0.011 | |
| CD19 + CD23+, % | 11.3 (7.43, 16.38) | 9.35 (6.05, 14.45) | 0.024 | |
| Deepening of lung marking, n (%) | 46(17.8) | 21(20.6) | 0.549 | |
| Dotted or small patchy shadows, n (%) | 183(70.7) | 75(73.5) | 0.608 | |
| Large lesions or solid shadows, n (%) | 30(11.6) | 6(5.9) | 0.12 | |
| Treatment | Oxygen support, n (%) | 47(17.4) | 11(10.5) | 0.096 |
| Mechanical ventilation, n (%) | 9(3.3) | 0 | — | |
| Admission to PICU, n (%) | 26(9.6) | 1(1.0) | 0.003 | |
| Length of stay, d | 7 (6, 9) | 7 (6, 9) | 0.99 |
Lypmphocyte subset analysis was performed in 212 patients in HBoV group and 83 patients in hMPV group.