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. 2023 Jan 10;13:1078526. doi: 10.3389/fimmu.2022.1078526

Figure 1.

Figure 1

Analysis of the primary structures of duGSDME, ducaspase-3 and ducaspase-7. (A) Comparison of the primary structure of duGSDME deduced from the amplified dugsdme gene (duGSDME_Amp) with the primary structure of predicted avian GSDME proteins (duGSDME_Ref infers duck GSDME, goGSDME_Ref infers goose GSDME, chGSDME_Ref infers chicken GSDME). (B) The 3-D model of duGSDME molecule predicted by SWISS-model. The duGSDME molecule shows typical structure characteristics of gasdermin proteins, which have two domains (NT and CT) linked by an unfolded peptide. (C) Comparison of the primary structure of ducaspase-3 deduced from the amplified ducaspase-3 gene (ducasp3_Amp) with the primary structure of predicted avian caspase-3 proteins (ducasp3_Ref infers duck caspase-3, gocasp3_Ref infers goose caspase-3, chcasp3_Ref infers chicken caspase-3). (D) Comparison of the primary structure of ducaspase-7 deduced from the amplified ducaspase-7 gene (ducasp7_Amp) with the primary structure of predicted avian caspase-7 proteins (ducasp7_Ref infers duck caspase-7, gocasp7_Ref infers goose caspase-7, chcasp7_Ref infers chicken caspase-7).