Table 4.
Comparison of characteristics between CTS‐screened patients with ATTRwt versus clinically diagnosed ATTRwt
| CTS‐screened ATTRwt (n = 10) | Matched clinical ATTRwt (n = 51) | P‐values | |
|---|---|---|---|
| Clinical | |||
| Age at diagnosis, years | 81.2 ± 7.6 | 79.7 ± 5.3 | 0.46 |
| Male | 9 (90) | 46 (90.4) | 0.97 |
| Hypertension | 6 (60.0) | 37 (72.5) | 0.43 |
| IHD | 2 (20.0) | 12 (23.5) | 0.81 |
| Atrial fibrillation | 2 (20.0) | 21 (40.3) | 0.24 |
| Pacemaker status | 0 (0.0) | 15 (29.4) | 0.04* |
| NYHA class (I/II/III–IV) | 7/3/0 (70/30/0) | 7/35/9 (13.5/69.2/17.3) | 0.00* |
| NAC stage (I/II/III) | 8/2/0 (80/20/0) | 22/17/12 (43.1/33.3/23.5) | 0.09 |
| Medications | |||
| Loop diuretics | 1 (10.0) | 38 (73.1) | 0.00* |
| ACE/ARB | 5 (50.0) | 31 (60.8) | 0.53 |
| Anticoagulants | 1 (10.0) | 32 (62.7) | 0.00* |
| Laboratory | |||
| Creatinine, μmol/L | 79.5 [65–89] | 98.1 [83–138] | 0.01* |
| eGFR, mL/min/1.73 m2 | 78.5 [67–90] | 60.0 [44–80] | 0.04* |
| Elevated troponin T or I | 6 (60.0) | 41 (80.4) | 0.15 |
| NT‐proBNP, ng/L | 742 [383–1157] | 2523 [980–4990] | 0.00* |
| Echocardiography | |||
| IVS, mm | 14.0 ± 3.0 | 17.3 ± 2.9 | 0.00* |
| PW, mm | 11.0 ± 2.6 | 14.1 ± 2.8 | 0.01* |
| LVEF, % | 55.6 ± 9.7 | 44.2 ± 10.5 | 0.02* |
| GLS, % | −15.5 ± 2.98 | −11.0 ± 3.1 | 0.01* |
| RASr | 1.8 [1.3–2.3] | 2.7 [2.2–3.5] | 0.01* |
| E/A ratio | 1.2 [0.99–2.1] | 1.5 [0.9–2.5] | 0.16 |
| E/e′ | 10.2 [8.7–12.5] | 12.3 [9.0–15.6] | 0.30 |
| TAPSE, mm | 23.8 ± 6.1 | 17.1 ± 4.2 | 0.00* |
ACE, angiotensin‐converting enzyme; ARB, angiotensin receptor blocker; ATTRwt, wild‐type transthyretin cardiac amyloidosis; CTS, carpal tunnel syndrome; eGFR, estimated glomerular filtration rate; GLS, global longitudinal strain; IHD, ischaemic heart disease; IVS, interventricular septum; LVEF, left ventricular ejection fraction; NAC, National Amyloidosis Centre; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; NYHA, New York Heart Association; PW, posterior wall; RASr, relative apical sparring ratio; TAPSE, tricuspid annular plane systolic excursion.
Summary statistics are presented as median [interquartile range 25–75] or mean ± SD for continuous variables and as numbers (%) for categorical data.
P < 0.05.