Table 1.
Associations between genetically predicted atrial fibrillation and cardiovascular diseases in sensitivity analyses
| Outcomes | Weighted median | MR‐Egger | Multivariable MR (Model 1 a ) | Multivariable MR (Model 2 b ) | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Coronary heart disease | 1.00 (0.95–1.05) | 0.961 | 0.95 (0.89–1.02) | 0.155 | 1.04 (0.98–1.11) | 0.148 | — | — |
| Hypertension | 1.08 (1.03–1.13) | 0.001 | 1.00 (0.92–1.09) | >0.999 | 1.10 (1.05–1.15) | <0.001 | 1.09 (1.05–1.14) | <0.001 |
| Heart failure | 1.23 (1.18–1.29) | <0.001 | 1.21 (1.13–1.30) | <0.001 | 1.29 (1.25–1.34) | <0.001 | 1.28 (1.24–1.33) | <0.001 |
| Ischaemic stroke | 1.23 (1.18–1.29) | <0.001 | 1.21 (1.14–1.29) | <0.001 | 1.22 (1.18–1.27) | <0.001 | 1.22 (1.17–1.27) | <0.001 |
| Transient ischaemic attack | 1.09 (1.00–1.18) | 0.038 | 1.02 (0.93–1.11) | 0.653 | 1.13 (1.06–1.21) | <0.001 | 1.13 (1.06–1.20) | <0.001 |
| Pulmonary embolism | 0.92 (0.82–1.03) | 0.155 | 0.94 (0.83–1.06) | 0.295 | 0.97 (0.89–1.07) | 0.562 | 0.97 (0.89–1.07) | 0.575 |
| Peripheral artery disease | 1.07 (0.98–1.18) | 0.141 | 1.07 (0.96–1.18) | 0.221 | 1.11 (1.02–1.20) | 0.011 | 1.09 (1.01–1.18) | 0.023 |
| Cardiac death | 1.04 (0.95–1.13) | 0.409 | 1.02 (0.91–1.13) | 0.766 | 1.05 (0.97–1.13) | 0.210 | 1.04 (0.97–1.12) | 0.297 |
CI, confidence interval; MR, Mendelian randomization; OR, odds ratio.
a
Smoking, body mass index, diabetes, and total cholesterol.
b
Model 1 + coronary heart disease.