Table 2.

Assessment of directional pleiotropy

Outcomes	Directional pleiotropy		Heterogeneity
	Intercept	P	Q	P
Coronary heart disease	0.005	0.07	202	<0.01
Hypertension	0.006	0.11	324	<0.01
Heart failure	0.002	0.45	223	<0.01
Ischaemic stroke	0	0.94	192	<0.01
Transient ischaemic attack	0.007	0.06	111	0.38
Pulmonary embolism	0.002	0.75	95	0.79
Peripheral artery disease	0.002	0.64	108	0.46
Cardiac death	0.006	0.20	127	0.09