Table 3.

Adjusted Cox models for mortality after discharge according to LVEF categories (normal EF: LVEF ≥ 50%; mildly reduced EF: LVEF 41–49%; and low EF: LVEF ≤ 40%)

	Low EF vs. normal EF		Mildly reduced EF vs. normal EF		Low EF vs. mildly reduced EF
	HR (95% CI)	P‐value	HR (95% CI)	P‐value	HR (95% CI)	P‐value
Unadjusted	1.93 (1.64–2.27)	<0.001	1.51 (1.20–1.90)	<0.001	1.28 (1.01–1.62)	0.043
Model 1	1.64 (1.36–1.96)	<0.001	1.33 (1.05–1.68)	0.019	1.23 (0.96–1.57)	0.095
Model 2	1.51 (1.19–1.93)	0.001	1.47 (1.08–1.99)	0.014	1.03 (0.75–1.41)	0.86
Model 3	1.52 (1.20–1.93)	0.001	1.43 (1.06–1.95)	0.021	1.06 (0.77–1.46)	0.72
Model 4	1.70 (1.43–2.02)	<0.001	1.32 (1.05–1.67)	0.019	1.29 (1.01–1.63)	0.040

CI, confidence interval; EF, ejection fraction; HR, hazard ratio; LVEF, left ventricular ejection fraction.

Model 1 was adjusted for sex, age, ST‐elevation myocardial infarction (STEMI), diabetes, dyslipidaemia, prior heart failure (HF), prior myocardial infarction (MI), prior coronary artery bypass graft (CABG), prior stroke, prior kidney disease, Killip class II or higher, use of beta‐blocker at discharge, and use of angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) at discharge; Model 2 was adjusted for the same variables in Model 1 plus Global Registry of Acute Coronary Events (GRACE) score and presence of multivessel coronary artery disease (CAD); Model 3 was adjusted for age, kidney disease, GRACE score, STEMI, use of ACEI/ARB at discharge, hypertension, diabetes, multivessel CAD, oral beta‐blockers in the first 24 h of hospitalization, prior stroke, prior HF, prior percutaneous coronary intervention, and prior CABG; and Model 4 was adjusted for covariates from the Model 1 that were considered confounders by the directed acyclic graph: sex, age, STEMI, diabetes, dyslipidaemia, prior HF, prior MI, and prior CABG.