TABLE 1.
Comparison of general information, serum parameters, and MTHFR C677T genotype of three groups of research subjects.
| n | Normotensive pregnancy group | Pregnancy-induced hypertension group | Preeclampsia group | p a * | p b * | p c * | p d * | |
| (n = 1,006) | (n = 131) | (n = 41) | ||||||
| Age | ||||||||
| ≥35 | 284 | 242 (24.06%) | 36 (27.48%) | 6 (14.63%) | 0.2432 | 0.3887 | 0.1924 | 0.1435 |
| <35 | 894 | 764 (75.94%) | 95 (72.52%) | 35 (85.37%) | ||||
| Weight (kilogram) | 56.4 ± 7.8 | 61.4 ± 8.2 | 59.4 ± 7.4 | <0.0001 | <0.0001 | 0.0145 | 0.2003 | |
| Body mass index (BMI) | 21.2 ± 3.0 | 22.7 ± 3.8 | 22.5 ± 2.8 | <0.0001 | <0.0001 | 0.0081 | 0.624 | |
| Number of embryos | ||||||||
| 1 | 1,082 | 925 (91.95%) | 122 (93.13*%) | 35 (85.37%) | 0.2722 | 0.733 | 0.1437 | 0.1997 |
| ≥2 | 96 | 81 (8.05%) | 9 (6.87%) | 6 (14.63%) | ||||
| Gravidity | ||||||||
| 1 | 389 | 336 (33.40%) | 41 (31.30%) | 12 (29.27%) | 0.3393 | 0.8905 | 0.1148 | 0.2063 |
| 2 | 460 | 386 (38.37%) | 52 (39.69%) | 22 (53.66%) | ||||
| ≥ 3 | 329 | 284 (28.23%) | 38 (29.01%) | 7 (17.07%) | ||||
| Parity | ||||||||
| 0 | 968 | 829 (82.41%) | 110 (83.97%) | 29 (70.73%) | 0.136 | 0.7146 | 0.0634 | 0.0709 |
| ≥ 1 | 210 | 177 (17.59%) | 21 (16.03%) | 12 (29.27%) | ||||
| Serum vitamin B12 concentration (pmol/L) | 393.7 ± 159.7 | 376.2 ± 137.2 | 339.6 ± 121.8 | 0.054 | 0.2319 | 0.0323 | 0.1276 | |
| Serum folate concentration (nmol/L) | 37.25 ± 10.73 | 39.92 ± 13.87 | 31.49 ± 7.374 | <0.0001 | 0.0099 | 0.0007 | 0.0003 | |
| Serum homocysteine concentration (μmol/L) | 4.261 ± 1.554 | 4.618 ± 2.077 | 4.668 ± 1.676 | 0.0222 | 0.0181 | 0.1001 | 0.8853 | |
| MTHFR C677T genotype | ||||||||
| CC | 356 | 304 (30.22%) | 38 (29.01%) | 14 (34.15%) | 0.9821 | 0.9577 | 0.8625 | 0.8216 |
| CT | 572 | 488 (48.51%) | 65 (49.62%) | 19 (46.34%) | ||||
| TT | 250 | 214 (21.27%) | 28 (21.37%) | 8 (19.51%) | ||||
* pa: Statistical difference among the three groups. pb: Statistical difference between normal pregnancy group and pregnancy induced hypertension group. pc: Statistical difference between normal pregnancy group and preeclampsia group; pd: Statistical difference between pregnancy-induced hypertension group and preeclampsia group.