Table 1:
Description of patients presenting with MIDANs.
| Characteristics | MIDANs (N = 28) |
|---|---|
| Demographics | |
| Age at diagnosis (years), median (IQR) | 52 (34–64) |
| Sex (male/female), n/n | 19/9 |
| BMI (kg/cm2), median (IQR) | 24 (20–27) |
| Kidney disease, n (%) | |
| Tubulointerstitial nephropathy | 14 (50) |
| Documented by kidney biopsy | 6 (21.4) |
| Glomerular disease | 9 (32.1) |
| FSGS | 3 (10.7) |
| Nephrotic syndrome | 3 (10.7) |
| Documented by kidney biopsy | 3 (10.7) |
| CAKUT | 4 (14.3) |
| Kidney cysts | 2 (7.1) |
| Urinary tract abnormalities | 2 (7.1) |
| Fanconi syndrome | 2 (7.1) |
| Other tubulopathy | 2 (7.1) |
| Kidney disease under the care of a nephrologist | 14 (50) |
| ESRD | 9 (32.1) |
| Transplantation | 4 (14.3) |
| Biological characteristicsa | |
| Urinalysis | |
| Protein/creatinine (g/g), median (IQR) | 0.6 (0.36–2.07) |
| Albumin/creatinine (g/g), median (IQR) | 0.37 (0–1.82) |
| Haematuria, n (%) | 1 (3.6) |
| Leukocyturia, n (%) | 12 (42.9) |
| Glycosuria, n (%) | 1 (3.6) |
| Blood ionogram, median (IQR) | |
| Calcium (mg/dl) | 9.3 (8.2–9.7) |
| Phosphorus (mg/dl) | 3.7 (3.4–4.3) |
| Sodium (mmol/l) | 139 (137–141) |
| Chloride (mmol/l) | 103.5 (101–106) |
| Glycemia (mg/dl) | 98.5 (88.3–108.1) |
| Potassium (mmol/l) | 4.41 (3.9–4.7) |
| Proteins (g/l) | 70.5 (64.75–74) |
| Albumin (g/l) | 38.1 (34.7–42.5) |
| Increased uric acid (female >5 mg/dl; male >6 mg/dl), n (%) | 11 (39.3) |
| GFR at diagnosis (ml/min/1.73 m2), median (IQR) | 60 (27–84) |
| GFR slopeb (ml/min/1.73 m2/year), median (IQR) | −3 (−6–0) |
BMI: body mass index; CPK: creatine phosphor-kinase.
aBiological characteristics at the time of MIDAN diagnosis.
bGFR slope during a median observation period of 26 months.
Conversion factors for units: serum calcium in mg/dl to mmol/l, × 0.2495; serum phosphorus in mg/dl to mmol/l, × 0.3229; serum glucose in mg/dl to mmol/l, × 0.05 551; uric acid in mg/dl to µmol/l, × 59.58.