The docking score and predicted protein–ligand interaction of four known inhibitors.

Compound	IFD score	Watvina docking score	Noncovalent interactions	Residues
Benzbromarone	−12.89	−7.6	2 Pi–Pi, 1 H-bond, 1 salt–bridge	Phe364, Phe365, Arg477
FYU-981	−9.38	−6.9	2 Pi–Pi, 3 H-bond, 3 salt–bridge	Phe241, Phe364, His245, Arg477
Lesinurad	−10.55	−7.3	2 Pi–Pi, 2 H-bond, 1 salt–bridge	Phe364, Arg477
Verinurad	−9.28	−8.1	2 Pi–Pi, 1 salt–bridge	Phe364, Arg477