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. 2023 Jan 10;13:1063002. doi: 10.3389/fimmu.2022.1063002

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Copyright © 2023 Iwasaki, Tharakaraman, Subramanian, Khongmanee, Hatas, Fleischer, Rurak, Ngok-ngam, Tit-oon, Ruchirawat, Satayavivad, Fuangthong and Sasisekharan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Thermal stability analysis of antibodies by differential scanning calorimetry (DSC). (A) The anti-EGFR/HER2 BsAb together with its parental mAb (pertuzumab) show two peaks of similar T_m values corresponding to the C_H2/Fab and C_H3 domains, with an extra peak at T_m 67.52°C. (B) The anti-CD20/CD20 BsAb exhibits similar T_m values for the C_H2/Fab and C_H3 domains when compared to its parental mAb (rituximab).