Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
CH1-CL mutations that favor the formation of cognate heavy-light pairing over mispairing. The CH1-CL of pertuzumab and DL11 are referred as CH1′-CL′ and CH1′′-CL′′, respectively.
| Pertuzumab | Q123D, N136D (CL′) | L133V, L150A (CH1′) |
| DL11 | Q123K, N136K, T177A (CL′′) | K152D, H173D, S188W (CH1′′) |
