TABLE 4.
GRADE profile of green tea extract supplementation for some cardiovascular risk factors in adults.
| Outcomes | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Number of intervention/control | Quality of evidence |
| TG | No serious limitation | Serious limitation1 | No serious limitation | Serious limitation2 | No serious limitation | 3,548 (1,825/1,723) | ⊕⊕○○ Low |
| TC | No serious limitation | Serious limitation1 | No serious limitation | No serious limitation | No serious limitation | 3,332 (1,698/1,634) | ⊕⊕⊕○ Moderate |
| LDL-C | No serious limitation | Serious limitation1 | No serious limitation | No serious limitation | No serious limitation | 3,139 (1,595/1,544) | ⊕⊕⊕○ Moderate |
| HDL-C | No serious limitation | Serious limitation1 | No serious limitation | No serious limitation | No serious limitation | 3,191 (1,627/1,564) | ⊕⊕⊕○ Moderate |
| FBS | No serious limitation | Serious limitation1 | No serious limitation | No serious limitation | No serious limitation | 2,905 (1,503/1,402) | ⊕⊕⊕○ Moderate |
| Fasting insulin | No serious limitation | Serious limitation1 | No serious limitation | Serious limitation2 | No serious limitation | 2,190 (1,136/1,054) | ⊕⊕○○ Low |
| HbA1c | No serious limitation | Serious limitation1 | No serious limitation | No serious limitation | No serious limitation | 992 (509/483) | ⊕⊕⊕○ Moderate |
| HOMA-IR | No serious limitation | Serious limitation1 | No serious limitation | Serious limitation2 | Serious limitation3 | 1,506 (775/731) | ⊕○○○ Very Low |
| SBP | No serious limitation | Serious limitation1 | No serious limitation | Serious limitation2 | No serious limitation | 1,899 (958/941) | ⊕⊕○○ Low |
| DBP | No serious limitation | Serious limitation1 | No serious limitation | No serious limitation | No serious limitation | 1,875 (946/929) | ⊕⊕⊕○ Moderate |
| CRP | No serious limitation | Serious limitation1 | No serious limitation | Serious limitation2 | No serious limitation | 907 (452/455) | ⊕⊕○○ Low |
FBS, fasting blood sugar; HbA1c, hemoglobin A1C; HOMA-IR, homeostatic model assessment for insulin resistance; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, triglyceride; LDL-C, low-density cholesterol; HDL-C, high-density cholesterol; and CRP, C-reactive protein.
1There is significant heterogeneity.
2There is no evidence of significant effects of green tea extract supplementation.
3There is significant publication bias.