Fig. 1.

Depicts neuromuscular impairments potentially contributing to performance fatigability in patients with CKD (yellow circle). Fatigue and perceived fatigability may act to further exacerbate performance fatigability (gray circles and dashed lines). Performance fatigability is defined as declines in objective measures of performance and perceived fatigability as the perceptual adjustments regulating activity performance. Fatigue represents a self-reported symptom defined as a subjective lack of physical and/or mental energy that is perceived by the individual to interfere with usual or desired activities.