TABLE 5.

Statistical analysis for PCA using effective parameter set for detecting the drug responses in human iPSC-derived astrocytes.

	vs. DMSO	vs. Acetaminophen	vs. 4-AP	vs. Chlorpromazine	vs. PTZ	vs. Picrotoxin	vs. Pilocarpine
Compounds	p value	p value	p value	p value	p value	p value	p value
DMSO	—	p = 0.101	**p = 4.30e-06	**p = 8.50e-07	**p = 1.12e-11	** p = 7.16e-06	**p = 1.92e-21
Acetaminophen	p = 0.101	—	**p = 5.66e-3	**p = 2.35e-09	**p = 2.62e-07	** p = 3.26e-07	**p = 1.35e-17
4-AP	**p = 4.30e-06	**p = 5.66e-3	—	**p = 4.1e-09	*p = 0.032	** p = 5.09e-13	**p = 1.12e-07
Chlorpromazine	**p = 8.50e-07	**p = 2.35e-09	**p = 4.1e-09	—	**p = 2.13e-12	** p = 6.44e-06	**p = 1.94e-22
PTZ	**p = 1.12e-11	**p = 2.62e-07	*p = 0.032	**p = 2.13e-12	—	** p = 1.39e-19	**p = 6.47e-06
Picrotoxin	**p = 7.16e-06	**p = 3.26e-07	**p = 5.09e-13	**p = 6.44e-06	**p = 1.39e-19	—	**p = 7.88e-26
Pilocarpine	**p = 1.92e-21	**p = 1.35e-17	**p = 1.12e-07	**p = 1.94e-22	**p = 6.47e-06	**p = 7.88e-26	—

4-AP (n = 6), pilocarpine (n = 6), picrotoxin (n = 6), PTZ (n = 6), chlorpromazine (n = 6), acetaminophen (n = 6), and DMSO (n = 6). One-way MANOVA. *p < 0.05, **p < 0.01.