Table 1.
Mechanism of potassium channel involved in tumor development.
| Potassium ion channel | Cancer types | Expression | Regulatory molecules | Functional role | References |
|---|---|---|---|---|---|
| Kv1.3 | Lung cancer | overexpression | CREB phosphorylation | Proliferation、Apoptosis | (15) |
| acute lymphoblastic leukemia | overexpression | AKT/ERK1/2/MYC signaling pathways | Drug target | (55) | |
| chronic lymphocytic leukemia | overexpression | n.d. | Apoptosis | (56) | |
| leukemia | overexpression | n.d. | Apoptosis、Drug target | (57) | |
| Pancreatic cancer | overexpression | n.d. | Drug target | (58) | |
| Kv1.5 | Breast cancer | overexpression | Cadherin-11/MAPK pathway | Migration | (16) |
| Kv7 | Colorectal cancer | downregulation | n.d. | Tumor inhibition | (10, 17) |
| Kv10.1 | Retinoblastoma | overexpression | n.d. | Promotion of tumor progression | (19) |
| Breast cancer | overexpression | MiR-126 | Tumor inhibition | (20) | |
| Acute myeloid leukemia | overexpression | n.d. | Drug target、Poor prognosis | (59) | |
| Kv11.1 | Breast cancer | downregulation | Facilitates Cav-1 dephosphorylation | Reduced cell invasion | (22) |
| Glioblastoma | overexpression | n.d. | Proliferation | (23) | |
| Medulloblastoma | overexpression | n.d. | Drug target | (60) | |
| KCa1.1 | Liver cancer | overexpression | n.d. | migration | (34) |
| Cervix carcinoma | overexpression | n.d. | Diagnostic markers | (61) | |
| KCa3.1 | Ovarian cancer | overexpression | P2y2 Purinergic | migration | (28) |
| Breast cancer | overexpression | EMT pathways | Proliferation 、migration | (29) | |
| Liver cancer | overexpression | MAPK/ERK/EMT pathways | Proliferation | (32) | |
| SKP2/EMT pathways | Migration | (33) | |||
| Papillary thyroid carcinoma | overexpression | EMT pathways | Migration | (38) | |
| Pancreatic cancer | overexpression | n.d. | Poor prognosis | (62) | |
| Leukaemia | overexpression | n.d. | Drug target | (63) | |
| Kir2.1 | Thyroid cancer | overexpression | EMT pathways | Proliferation 、migration、Poor prognosis | (28) |
| gastric cancer | overexpression | Serine/Threonine protein kinase 38 | prognostic marker | (64) | |
| Kir2.3 | Lung cancer | overexpression | lncRNA POU6F2-AS1/miR-34c-5p | Poor prognosis | (39) |
| Kir4.2 | Kidney cancer | downregulation | EMT pathways/Matrix metalloproteinase-7/P21 | Proliferation、migration、Apoptosis | (42) |
| Kir6.2 | Ovarian cancer | downregulation | n.d. | Prognosis | (40) |
| TREK-1 | Liver cancer | downregulation | n.d. | Prognosis | (46) |
| TASK-1 | Lung cancer | overexpression | AMPK-TXNIP Pathway | Proliferation、migration、Apoptosis | (47) |
| TASK-3 | Breast cancer | overexpression | CDK/Cyclin complexes | Proliferation | (51) |
| Gastric cancer | overexpression | n.d. | Proliferation、Apoptosis | (52) | |
| TWIK-2 | Breast cancer | overexpression | n.d. | Proliferation、Apoptosis | (50) |