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. 2022 Jul 4;72(2):381–391. doi: 10.1136/gutjnl-2022-327196

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Association between novel (TERT) and confirmed loci (PNPLA3, TM6SF2) with HCC and cirrhosis phenotypes. ORs and 95% CIs for the susceptibility loci for alcohol-related HCC and alcohol-related cirrhosis (ArC) in comparison to alcohol misusers without cirrhosis (AM). The comparison HCC vs ArC displays allelic ORs of combined stage 1 and 2 samples (meta-analysis), derived from allele dosage data, adjusted for age, sex, BMI, type 2 diabetes status and top 15 principal components of genetic ancestry. *The comparison HCC versus AM and ArC versus AM display unadjusted allelic ORs derived from 2×2 contingency tables of allele counts observed in the total cohort, provided in online supplemental tables 2–4. BMI, body mass index; HCC, hepatocellular carcinoma.