Figure 3.

Yearly progression of total airway disease (A, B) and bronchiectasis (C, D) throughout the study period versus mean LCI_adj (A, C) and progression of LCI_adj (B, D) over the same period. Circles show the best linear unbiased predictions (BLUPs) of each subject’s progression and mean, estimated by joint modelling of all longitudinal chest CT and MBW data. ‘r’ is the corresponding correlation coefficient. The solid lines with shaded bands are fitted regression lines with 95% confidence limits. LC, lung clearance index; MBW, multiple breath washout.