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. 2022 Oct 31;109(3):178–185. doi: 10.1136/heartjnl-2022-321114

Table 1.

Dose reduction criteria of NOACs18

NOAC Dose reduction criteria Reduced dose
Dabigatran Creatinine clearance: 50 mL/min Variable doses below full 110 mg dose recommended in ESC guidelines
Rivaroxaban Creatinine clearance: 50 mL/min 15 mg once a day
Apixaban 2 of 3 criteria: age ≥80 years, weight ≤60 kg, creatinine ≥1.5 mg/dL 2.5 mg two times a day
Edoxaban Creatinine clearance: ≤50 mL/min 30 mg once a day

NOAC, non-vitamin K antagonist oral anticoagulant.