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. 2023 Jan 24;16:6. doi: 10.1186/s13045-023-01398-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Protein degradation regulates drug efflux. ABCC1, ABCB1, and ABCG2 are the three main drug transporters. NEDDL ligases the ubiquitin chain to ABCC1, while USP22 and USP24 eliminate the ubiquitin chain. CUL3 regulates ABCC1 expression by modulating the degradation of NRF2. MARCH8, FBXO15, and FBXO21 ligase the ubiquitin chain on ABCB1, and USP24 acts as the DUB. USP24 is the DUB of ABCG2. RNF180 and UCHL3 indirectly regulate the expression of ABCG2