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. 2023 Jan 24;16:6. doi: 10.1186/s13045-023-01398-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Current technologies targeting protein degradation. a PROTAC is designed to conjugate specific E3 ligases and proteins of interest for further degradation. b Based on the E3 ligase activity of IAPs, SNIPERs conjugate IAPs and proteins of interest for degradation. c TRIM21 has high affinity for antibodies. Therefore, using specific antibodies against the proteins of interest can lead to rapid degradation. d AUTAC is a heterobifunctional compound with a targeting warhead and a tag that recruits the autophagy system, which may lead to ubiquitin-dependent selective degradation through lysosomal degradation. e AUTOTAC connects the protein of interest and p62 for autophagy-induced protein degradation. f ATTEC conjugates the protein of interest and LC3 for degradation. g LYTAC interacts with membrane proteins or extracellular proteins and the CI-M6PR for endocytosis