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. 2023 Jan 24;25:9. doi: 10.1186/s13058-023-01609-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Circular Manhattan plot displaying the associations between blood metabolites and the risk of breast cancer. The red dashed line represents the Bonferroni-corrected significance threshold (P < 0.05/112 = 4.46 × 10^–4), and the labels are provided for significant metabolites. The 112 blood metabolites are grouped and color-coded by super-pathway listed in Table S1. The detailed results for the associations between blood metabolites and breast cancer by inverse-variance weighted Mendelian randomization analysis are presented in Table S4