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. 2023 Jan 24;25:9. doi: 10.1186/s13058-023-01609-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Potential on-target side effects associated with HDL-C and acetate. Odds ratios (ORs) with their 95% confidence intervals (CIs) represent the effect estimates on the risk of multiple non-breast cancer diseases of per 10% reduction in risk for breast cancer by targeting HDL-C and acetate, respectively. Associations above the horizontal black midline represent deleterious side effects. In contrast, associations below the horizontal black midline represent beneficial side effects