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. 2023 Jan 23;15:12. doi: 10.1186/s13148-023-01430-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — AZM attenuates overexpression of P65, EZH2 and H3K27me3 and cytokines and alleviates wheezing time. A–C The expression levels of P65, EZH2 and H3K27me3 were examined by Western blotting (n = 4). D–G Effects of AZM on IL-2, IL-6, IL-10 and INF-γ in the BALF (n = 3). H Three shEZH2 intervention sites were used to optimize the transfection efficiency, and that of the lentiviral vector was analyzed by immunofluorescence containing EZH2 shRNA. Scale bars indicate 100 μm. I Lentiviral transfection efficiency of shEZH2 was analyzed by Western blotting. ^#P < 0.05 versus the shCtrl group (n = 3). J, K The expression of EZH2 and H3K27me3 after shEZH2 intervention was detected by protein immunoblotting. ^&P < 0.05 versus the Wheeze + shCtrl group (n = 3). L Effects of AZM on wheezing time in patients. M Effects of mycoplasma infection on AZM and wheezing time. *P < 0.05 versus the Wheeze group