KEY RESOURCES TABLE

Resource Type	Specific Reagent or Resource	Source or Reference	Identifiers	Additional Information
Add additional rows as needed for each resource type	Include species and sex when applicable.	Include name of manufacturer, company, repository, individual, or research lab. Include PMID or DOI for references; use “this paper” if new.	Include catalog numbers, stock numbers, database IDs or accession numbers, and/or RRIDs. RRIDs are highly encouraged; search for RRIDs at https://scicrunch.org/resources.	Include any additional information or notes if necessary.
Antibody	Melanin Concentrating Hormone(MCH) (human,Rat, Mouse) Antibody; host: rabbit	Phoenix Pharmaceuticals,Inc.	Catalog No: H-070-47 lot No: 01629-9
Antibody	Donkey Anti-Rabbit IgG H&L (Alexa Fluor® 488)	Abcam	AB150073
Antibody	Donkey Anti-Rabbit IgG H&L (Alexa Fluor® 594)	Abcam	AB150076
Viral Strain	Adeno-Associated Virus serotype 5 (AAV5)	University of North Carolina Vector Core
Chemical Compound or Drug	Picrotoxin (PTX)	Tocris	#1128
Chemical Compound or Drug	1-Naphthylacetyl Spermine Trihydrochloride (Naspm)	Toronto Research Chemicals	N377800
Chemical Compound or Drug	Clozapine N-oxide (CNO)	Tocris	#6329
Chemical Compound or Drug	Clozapine N-oxide (CNO)	NIMH Chemical Synthesis and Drug Supply Program	#C-929
Chemical Compound or Drug	(−)-Cocaine hydrochloride	NIDA Drug Supply Program	#9041-001
Commercial Assay Or Kit	ZymoPURE II plasmid maxiprep kit	Zymo Research	#D4202
Organism/Strain	Rats/ Spargue-Dawley	Envigo
Peptide, Recombinant Protein	Melanin-concentrating hormone (MCH) peptide	Tocris	#3806
Recombinant DNA	GCaMP6f	Addgene	#52925
Recombinant DNA	AAV5-MCHp-DREADDs(Gq)-mCherry	PMID: 33093653
Recombinant DNA	AAV5-MCHp-GFP	kindly provided by Dr. Priyattam Shiromani
Recombinant DNA	AAV5-MCHp-ChR2-EYFP	PMID: 33093653