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. 2022 Sep 2;11(3):778–795. doi: 10.1556/2006.2022.00057

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© 2022 The Author(s)

Open Access. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.

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Fig. 4. — The results of the interaction effect for whole-brain activation analysis

A: Brain regions showing a significant interaction effect (Group × Sex) on whole-brain activation. B: The post hoc result for brain activation in the L-putamen (the coordinate indicates the peak voxel of this cluster). C: The brain activation of the L-putamen showed a significant positive correlation with log(h) values among the IGD group but not among the RGU group. D: The post hoc result for brain activation in the vmPFC/ACC (the coordinate indicates the peak voxel of this cluster). E: Brain activation of the vmPFC/ACC showed a significant negative correlation with IAT scores among males but not among females. Abbreviations: IGD = internet gaming disorder; RGU = recreational game user; IAT = Internet Addiction Test; L = left; vmPFC = ventromedial prefrontal cortex; ACC = anterior cingulate cortex; *, P < 0.05; **, P < 0.01; ***, P < 0.001.