Table 2.
Bivariate analyses: genetic characteristics of patients with and without ICBs (N = 156)
(among all the SNPs explored, the OPRM1 rs1799971 polymorphism was the only potential candidate for the final multivariate model)
| Genotype | Total sample (N = 156) | No ICB (N = 102) | ICBs (N = 54) | P-value | |
| OPRM1 rs1799971 | AA | 109 (69.9%) | 65 (63.7%) | 44 (81.5%) | 0.0541 |
| AG | 40 (25.6%) | 32 (31.4%) | 8 (14.8%) | ||
| GG | 7 (4.5%) | 5 (4.9%) | 2 (3.7%) |
In the whole sample, the allele frequency was 82.7% for the A allele (258/312) and 17.3% for the G allele (54/312).
The G allele frequency differed across groups: 11.1% in the “ICB” group (12/108) and 20.6% in the “no ICB” group (42/204).