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Spontaneous mutations that confer resistance to GSK286
| Mutant | Location, gene | Mutation/result |
|---|---|---|
| GSK1 | Glu293 (GAG), rv1625c | Gly (GGG) |
| GSK2 | Trp199 (TGG), rv1625c | STOP (TGA) |
| GSK3 | After Phe96, rv1625c | Extra G (frameshift to stop at 204) |
| GSK4 | 14-bp insert Glu332, rv1625c | Frameshift to stop at 338 |
| GSK5 | Phe283 (TTC), rv1625c | Ser (TCC) |
| GSK6 | Tyr393 (TAC), rv1625c | Asp (GAC) |
| GSK7 | Asp369 (GAC), rv1625c | Tyr (TAC) |
| GSK8 | Unknown | Unknown |
| GSK9 | Unknown | Unknown |
| GSK10 | Unknown | Unknown |
