FIG 2.

Heatmap of SARS-CoV-2 point mutations in the mutant spectrum of SARS-CoV-2 populations grown in the absence (no drug) or presence of ribavirin (Rib), with a cutoff mutation frequency of 0.1%. Frequency values are color coded, as depicted in the upper box. Data are presented in two blocs, one for the nsp12 (polymerase)-coding region (genomic residues 14,534 to 16,054) and another for the S-coding region (genomic residues 22,872 to 23,645). Only positions with a mutation are represented; mutations have been identified relative to GenBank accession no. NC_045512. The complete set of mutations, their frequency and type, codon position, amino acid substitutions, tolerability, and potential functional effect are given in Table S3 at https://saco.csic.es/index.php/s/So94ey5ECYgMZdX. Procedures are detailed in Materials and Methods.