FIG 2.

Occurrence and cooccurrence of mechanisms of antimicrobial resistance identified in 22/24 isolates of E. coli with cefepime-taniborbactam MICs of ≥16 μg/mL. Major porin genes, ompC and ompF, were screened for alterations that code for a truncated, presumably nonfunctional protein. PBP3 sequence mutation includes ftsI sequences predicted to code insertions known to reduce cefepime binding. Predicted efflux upregulation includes genetic changes that likely enhance drug extrusion.