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Occurrence and cooccurrence of mechanisms of antimicrobial resistance identified in 204/267 isolates of P. aeruginosa with cefepime-taniborbactam MICs of ≥16 μg/mL. Resistance factors include the presence of IMP family MBLs, mutation in the ftsI sequence predicted to code for PBP3 variants with reduced cefepime binding, and predicted efflux upregulation that includes genetic changes that likely enhance drug extrusion.
