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. 2023 Jan 4;12:1089991. doi: 10.3389/fcimb.2022.1089991

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Copyright © 2023 Wu, Zhang, Chen, Xia, Zhu, Chen, Lin, Zheng, Hou, Li, Zhang, Chen and Hou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in gut microbiota between week 0 and week 4 in T2DM patients after interventions. (A) Differences in alpha diversity indexes, microbial richness (Observed index and Chao1 index), Shannon diversity, and evenness. (B) Relative abundances of the top phyla in the these groups; Changes in gut microbiota and microbial colonization of donor-derived microbiota in subjects with type 2 diabetes. (C) Differences in beta diversity between baseline (W0) and week 4 (W4) after intervention by metformin, FMT, or FMT plus metformin, visualized by PCA. (D, F) The colonization of donor-derived microbiota in FMT alone and FMT plus metformin groups. (E) Changes of Euclidean distance between W0 and W4. (G) Changes of Euclidean distance between W4 and donors.