Fig. 10. The response of cell-cell interactions to vagal nerve stimulation in neuronal and glial subsets.

The alterations were estimated through differential expression (p-value) of ligands (sky blue) and receptors (orange) expressed in neuronal and glial subsets in myenteric ganglia (MG) with vagal nerve stimulation (VNS) compared with those without VNS. + labels the upregulated interaction of cell subsets where there are the genes expressing ligands/receptors with smaller p-value under VNS. The upregulated a and downregulated b genes encoding both ligands and receptors in myenteric ganglia (MG) with or without VNS were compared between the porcine proximal and distal colon (p-pC, p-dC).