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. 2023 Jan 24;6:98. doi: 10.1038/s42003-023-04478-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Probability distributions of human-porcine regional datasets selected from the high-quality orthologous gene list between myenteric ganglia (MG) from porcine proximal, transverse and distal colon (p-pC, p-tC, p-dC) and in parallel from human ascending, transverse and descending colon (h-aC, h-tC, h-dC) a, Spearman’s Correlation b, and evaluation of goodness of fit c. Color in b represents a correlation distribution from big (dark red) to small (light blue). Cartoon diagram showing regional differentially expressed gene (DEG) network matching between human and pig d. Gene Ontology Biological Processes terms (pathways) are shown as circles (nodes) that are connected with lines (edges) if the terms share many genes. Nodes are colored in purple (without VNS) and in light green (with VNS), and edges are sized on the basis of the number of genes shared by the connected pathways. FLs functional linkages, VNS vagal nerve stimulation, Up upregulated expression, Down downregulated expression.