Table 1.
The extended family of protein phosphatases
| Superfamily | Family | Class | Subclass | Example enzyme |
|---|---|---|---|---|
| PTP | Cys-based | 1 | RPTP | VE-PTP and CD45 |
| NRPTP | TC-PTP and SHP1 | |||
| MKP DSP | PAC1 | |||
| Atypical DSP | JKAP | |||
| 2 | LMPTP | LMPTP | ||
| SSu72 | SSu72 | |||
| 3 | CDC25 | CDC25A/CDC25B/CDC25C | ||
| His-based | HP | UBASH3 | UBASH3A/UBASH3B | |
| PSP | PPP | PP1 | PP1 | |
| PP2A | PP2A | |||
| PP2B/calcineurin | PP2B/calcineurin | |||
| PP4 | PP4 | |||
| PP5 | PP5 | |||
| PP6 | PP6 | |||
| PP7 | PP7 | |||
| PPM | PPM | WIP1 | ||
| PDP | PDP1/PDP2 | |||
| HAD | Asp-based | EYA | EYA1/EYA2/EYA3/EYA4 | |
| FCP/SCP | FCP and SCP | |||
CDC25, cell division cycle 25; DSP, dual-specificity phosphatase; EYA, eyes absent; FCP, FIIF-associating component of RNA polymerase II C-terminal domain phosphatase; HAD, haloacid dehalogenase; HP, histidine phosphatase; LMPTP, low-molecular-weight PTP; MKP, MAP kinase phosphatase; NRPTP, non-receptor PTP; PDP, pyruvate dehydrogenase phosphatase; PPM, metal-dependent protein phosphatase; PPP, phosphoprotein phosphatase; PSP, protein serine/threonine phosphatase; PTP, protein tyrosine phosphatase; SCP, small C-terminal domain phosphatase; SHP1, SH2 domain-containing PTP 1; SSu72, suppressor of Sua7-2; TC-PTP, T cell PTP; UBASH3, ubiquitin-associated and Src homology 3 domain-containing; VE-PTP, vascular endothelial PTP; WIP1, wild-type p53-induced phosphatase 1.