Table 3.
Meropenem PK Parameters—Median (with Range)—Estimated by Noncompartmental Analysis, by Arm
| Study Arm and Meropenem Dose | AUC0–24 (h · mg/L) | Cmax (mg/L) | Half-Life (h) | n |
|---|---|---|---|---|
| C (2 g TID, with rifampin) | 574 (377–776) | 123 (99.2–201) | 1.15 (0.92–2.17) | 12 |
| D (2 g TID) | 534 (317–937) | 129 (82.6–187) | 1.09 (0.79–1.28) | 13 |
| E (1 g TID) | 253 (135–730) | 66 (37.6–131) | 1.09 (0.84–3.25) | 12 |
| F (3 g QD) | 309 (198–423) | 174 (109–254) | 1.00 (0.64–1.19) | 12 |
Definition of abbreviations: AUC = area under the concentration–time curve; Cmax = maximum plasma concentration; n = number of patients who underwent PK sampling; PK = pharmacokinetic; QD = once daily; TID = every 8 hours.
Note that all patients received amoxicillin/clavulanate with each meropenem dose.