Table 4.
Model-based Bayesian Predicted Median and 2.5th–97.5th Percentiles of Individual EBA for 0–2, 0–7, and 0–14 Days in CFU Count and TTP, by Arm
| Individual EBA* | Mero 2 g TID + Amx/Clv + Rifampin (Arm C) | Mero 2 g TID + Amx/Clv (Arm D) | Mero 1 g TID + Amx/Clv (Arm E) | Mero 3 g QD + Amx/Clv (Arm F) |
|---|---|---|---|---|
| CFUs (log10 CFUs/ml) | ||||
| 0–2 | 0.43 (0.25–0.66) | 0.24 (0.11–0.43) | 0.12 (0.066–0.20) | 0.11 (0.07–0.16) |
| 0–7 | 1.5 (0.86–2.3) | 0.84 (0.40–1.5) | 0.42 (0.23–0.68) | 0.38 (0.25–0.57) |
| 0–14 (overall) | 3.0 (1.7–4.6) | 1.7 (0.80–3.0) | 0.83 (0.46–1.4) | 0.75 (0.49–1.1) |
| 0–14 (per day) | 0.22 (0.12–0.33) | 0.12 (0.057–0.21) | 0.059 (0.033–0.097) | 0.053 (0.035–0.081) |
| TTP (log10 h) | ||||
| 0–2 | 0.13 (0.074–0.24) | 0.016 (0.007–0.052) | 0.013 (0.005–0.033) | 0.017 (0.006–0.058) |
| 0–7 | 0.24 (0.16–0.44) | 0.057 (0.026–0.18) | 0.047 (0.017–0.114) | 0.059 (0.02–0.20) |
| 0–14 | 0.34 (0.21–0.75) | 0.11 (0.052–0.37) | 0.094 (0.034–0.23) | 0.12 (0.04–0.42) |
Definition of abbreviations: Amx/Clv = amoxicillin/clavulanate; CFUs = colony-forming units; EBA = early bactericidal activity; Mero = meropenem; QD = once daily; TID = every 8 hours; TTP = time to positive culture.
EBACFU0–2, EBACFU0–7, and EBACFU0–14 are reported by overall change in CFUs over the time interval. EBACFU0–14 is also described as decrease in log10 CFUs/ml per day (averaged over 14 d) for comparability to other studies. EBA and TTP are reported by overall change in TTP over the time interval.
*
Individual EBA was based on the empirical Bayes estimates (see online supplement).