Table 1.
Clinical Data and Cytogenetic Abnormalities of 314 Patients With Uveal Melanoma
| Characteristics | Full Sample (n = 314) n (%) | Choroidal Melanoma (n = 217) n (%) | Ciliary Body Involved Melanoma (n = 97) n (%) | P Value |
|---|---|---|---|---|
| Age, y (mean, SD) | 60.9 (11.6) | 60.8 (11.5) | 61.2 (11.9) | 0.754 |
| Gender | 0.029 | |||
| F | 146 (46.5) | 92 (42.4) | 54 (55.7) | |
| M | 168 (53.5) | 125 (57.6) | 43 (44.3) | |
| AJCC tumor size | <0.001 | |||
| T1 | 51 (16.2) | 40 (18.4) | 11 (11.3) | |
| T2 | 116 (36.9) | 99 (45.6) | 17 (17.5) | |
| T3 | 127 (40.4) | 70 (32.3) | 57 (58.8) | |
| T4 | 20 (6.4) | 8 (3.7) | 12 (12.4) | |
| AJCC stage | <0.001 | |||
| I | 40 (12.7) | 40 (18.4) | 0 (0) | |
| II | 196 (62.4) | 166 (76.5) | 30 (30.9) | |
| III | 78 (24.8) | 11 (5.1) | 67 (69.1) | |
| Monosomy 3 | <0.001 | |||
| No | 161 (51.3) | 129 (59.4) | 32 (33) | |
| Yes | 153 (48.7) | 88 (40.6) | 65 (67) | |
| 8q gain | <0.001 | |||
| No | 165 (52.5) | 129 (59.4) | 36 (37.1) | |
| Yes | 149 (47.5) | 88 (40.6) | 61 (62.9) | |
| 6p gain | 0.360 | |||
| No | 212 (67.5) | 143 (65.9) | 69 (71.1) | |
| Yes | 102 (32.5) | 74 (34.1) | 28 (28.9) | |
| 8p gain | 0.989 | |||
| No | 288 (91.7) | 199 (91.7) | 89 (91.8) | |
| Yes | 26 (8.3) | 18 (8.3) | 8 (8.2) | |
| 6q loss | 0.091 | |||
| No | 251 (79.9) | 179 (82.5) | 72 (74.2) | |
| Yes | 63 (20.1) | 38 (17.5) | 25 (25.8) | |
| 8p loss | 0.920 | |||
| No | 271 (86.3) | 187 (86.2) | 84 (86.6) | |
| Yes | 43 (13.7) | 30 (13.8) | 13 (13.4) | |
| 1p loss | 0.131 | |||
| No | 261 (83.1) | 185 (85.3) | 76 (78.4) | |
| Yes | 53 (16.9) | 32 (14.7) | 21 (21.6) | |
| 6p loss | 0.309 | |||
| No | 313 (99.7) | 217 (100) | 96 (99) | |
| Yes | 1 (0.3) | 0 (0) | 1 (1) | |
| 6q gain | 0.729 | |||
| No | 304 (96.8) | 209 (96.3) | 95 (97.9) | |
| Yes | 10 (3.2) | 8 (3.7) | 2 (2.1) | |
| 8q loss | >0.999 | |||
| No | 308 (98.4) | 212 (98.1) | 96 (99) | |
| Yes | 5 (1.6) | 4 (1.9) | 1 (1) | |
| Metastatic | 0.002 | |||
| No | 247 (78.7) | 181 (83.4) | 66 (68) | |
| Yes | 67 (21.3) | 36 (16.6) | 31 (32) |
AJCC, American Joint Committee on Cancer; SD, standard deviation.