Table 7.
Pediatric versus adult comparison
| Parameter | Pediatric | Adult | P |
|---|---|---|---|
| No. of cases | 28 | 97 | |
| Mean age, years (SD) | 12 (4.5) | 44 (12.7) | 0.00 |
| Female | 39% | 66% | 0.02 |
| RPGN | 14% | 43% | 0.01 |
| Gross hematuria | 46% | 23% | 0.03 |
| Oliguria | 25% | 60% | 0.00 |
| AKI | 57% | 83% | 0.01 |
| Mean creatinine mg/dl (SD) | 1.7 (1.1) | 4 (3.3) | 0.00 |
| Creatinine>4 mg/dl | 10% | 41% | 0.00 |
| Low C3 | 78% | 62% | 0.16 |
| Low C4 | 22% | 10% | 0.09 |
| Normal C3 and C4 | 22% | 38% | 0.16 |
| Biopsy need | 29% | 80% | 0.00 |
| C3 deposition | 100% | 100% | 1.00 |
| C3 2+dominance | 50% | 57% | 0.73 |
| IgA dominance | 0% | 5% | 1.00 |
| ECP | 100% | 92% | 0.08 |
| Mesangial proliferation | 50% | 22% | 0.10 |
| Crescent>20% | 0% | 17% | 0.35 |
| Global GS>10% | 0% | 37% | 0.05 |
| IFTA | 0% | 22% | 0.20 |
| No infection focus identified | 0% | 33% | 0.00 |
| RRT requiring | 4% | 28% | 0.00 |
| CKD progression | 4% | 42% | 0.00 |
| ESRD | 0% | 15% | 0.04 |
| Death | 0% | 12% | 0.07 |
CKD: Chronic kidney disease, ESRD: End-stage renal disease, RPGN: Rapidly progressive glomerulonephritis, RRT: Renal replacement therapy, SD: Standard deviation, ECP=endocapillary proliferation