TABLE 2. Performance Endpoints.

cAHI cutoff		cAHI	cAHI	cAHI
Sensitivity (%)	PPG – EXPERT	78.1 [63.8, 92.4]	81.0 [64.2, 97.8]	72.7 [46.4, 99.0]
	LOCAL – EXPERT	71.9 [56.3, 87.5]	57.1 [35.9, 78.3]	72.7 [46.4, 99.0]
Specificity (%)	PPG – EXPERT	95.3 [92.5, 98.1]	99.1 [97.9, 100.0]	97.8 [95.9, 99.7]
	LOCAL – EXPERT	95.3 [92.5, 98.1]	99.1 [97.9, 100.0]	98.3 [96.6, 100]
LR+	PPG – EXPERT	16.6 [8.8, 31.3]	90.7 [22.5, 365.9]	34.0 [13.3, 87.1]
	LOCAL – EXPERT	15.3 [8.1, 29.1]	64.0 [15.3, 267.1]	42.5 [15.1, 120.0]
LR-	PPG – EXPERT	0.23 [0.12, 0.44]	0.19 [0.08, 0.46]	0.28 [0.11, 0.73]
	LOCAL – EXPERT	0.30 [0.17, 0.51]	0.43 [0.26, 0.71]	0.28 [0.11, 0.73]
PPV (%)	PPG – EXPERT	71.4 [56.4, 86.4]	89.5 [75.7, 100.0]	61.5 [35.0, 88.0]
	LOCAL – EXPERT	69.7 [54.0, 85.4]	85.7 [67.4, 100.0]	66.7 [40.0, 93.4]
NPV (%)	PPG – EXPERT	96.7 [94.3, 99.1]	98.2 [96.5, 99.9]	98.7 [97.2, 100.0]
	LOCAL – EXPERT	95.8 [93.1, 98.5]	96.1 [93.6, 98.6]	98.7 [97.2, 100.0]
Accuracy (%)	PPG – EXPERT	93.1 [89.9, 96.3]	97.6 [95.7, 99.5]	96.7 [94.5, 98.9]
	LOCAL – EXPERT	92.2 [88.8, 95.6]	95.5 [92.9, 98.1]	97.1 [95.0, 99.2]
Cohen’s Kappa	PPG – EXPERT	0.71 [0.57, 0.84]	0.84 [0.71, 0.97]	0.65 [0.41, 0.89]
	LOCAL – EXPERT	0.66 [0.52, 0.81]	0.66 [0.47, 0.86]	0.68 [0.45, 0.91]
ROC AUC	PPG – EXPERT	0.94	0.98	0.98
	LOCAL – EXPERT	NA	NA	NA
PR AUC	PPG – EXPERT	0.80	0.79	0.62
	LOCAL – EXPERT	NA	NA	NA

95% confidence interval estimates for the performance endpoints are shown in brackets. PPG – EXPERT refers to the PPG-based method’s predictions compared to Expert Analysis. LOCAL – EXPERT refers to the Local Analysis compared to the Expert Analysis. cAHI = central apnea-hypopnea index. AUC = area under curve, NPV = negative predictive value, PPV = positive predictive value, ROC = receiver operating characteristic, PPG = photoplethysmography.