Table 3. Multiple logistic regression analysis for risk factors associated with pDDIs in chronic disease patients.

	Univariate logistic regression (N = 220)			Multivariable logistic regression (N = 220)
Variables	OR	95% CI	P value	OR	95% CI	p value
Gender, male	0.88	0.31–1.23	0.11	0.72	0.52–1.08	0.28
Older age ≥ 60 years	2.17	1.32–3.11	<0.001	1.95	1.44–2.37	<0.001
Polypharmacy (≥ 5 drugs)	4.94	2.26–6.67	<0.001	3.74	2.32–4.54	<0.001
Overburden a	3.02	1.63–5.76	<0.01	2.23	1.64–3.16	<0.01
CCI score	1.87	1.13–3.07	<0.001	1.28	1.04–1.84	<0.001
multiple prescribers to one patient	1.51	1.27–2.13	<0.001	1.18	1.06–1.41	<0.01
trainee practitioner	1.32	1.09–1.77	<0.01	1.09	1.01–1.28	<0.01
prescription by a specialist	0.88	0.53–0.98	<0.01	0.83	0.55–1.17	0.09
presence of previous medical record	0.73	0.49–0.95	<0.01	0.63	0.37–1.24	0.16
use of online software in prescription generation	0.69	0.51–0.86	<0.01	0.66	0.45–1.22	0.15
review of prescription by clinical pharmacist	0.63	0.34–0.88	<0.01	0.58	0.27–0.89	0.37

OR, odd ratio; p <0.01 was considered statistically significant;

^a ≥20 patients in one hour; CCI, charlson comorbidity index.